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KMID : 0941820010110020057
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Korean Journal of Clinical Pharmacy
2001 Volume.11 No. 2 p.57 ~ p.61
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The Effect of Circadian Rhythm on the Pharmacokinetics of Acebutolol after Intravenous Administration to Rabbits
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Abstract
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The effect of circadian rhythm on the pharmacokinetics of acebutolol was studied in rabbits administered intravenous 5 mg/kg dose of acebutolol at 09:00 in the morning (a.m) and 22:00 in the evening (p.m). A significant effect of circadian rhythm of pbarmacokinetic parameters as a function of time of day was noted in rabbits, showing lower total body clearance (CLt), higher plasma concentration and the area under the plasma concentration time curve (AUC) when acebutolol was given in the evening. The plasma concentration of acebutolol was increased significantly (p<0.05) at 12-24 hr after dosing in the evening. The AUC was greater in the evening (111%) than that in the morning and CL_t, was higher when acebutolol was given in the morning (1.12pm0.24 ml/hr) versus in the evening (1.01pm0.22 ml/hr), but those were not significant. Therefore, It is reasonable to consider individual circadian rhythm for effective dosage regimen of acebutolol in clinical chronotherapeutics.
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